Verapamil Impurity 35 HCl CAS 77326-93-3 (free base)
| CAS No. | 77326-93-3 (free base) |
| Molecular Formula | C26H36N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Verapamil Impurity 35 HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Verapamil Impurity 35 HCl (CAS 77326-93-3 (free base), C26H36N2O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Verapamil Impurity 35 HCl (C26H36N2O4HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Verapamil Impurity 35 HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H36N2O4 HCl |
| Molecular Weight | 477.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 38 (CAS 114847-42-6)
- Verapamil D6 HCl (CAS 1185032-80-7)
- Verapamil-d7 Hydrochloride (CAS 1188265-55-5)
- Verapamil EP Impurity G (CAS 120-14-9)
- Verapamil EP Impurity J-D7 HCl (CAS 1216413-74-9)
- Verapamil EP Impurity B HCl (CAS 13078-76-7)
- (S)-(-)-Verapamil-d6 Hydrochloride (CAS 1329611-24-6)
Recommended Standards
- Imatinib Impurity 36 (CAS 475587-23-6)
- Bosutinib Impurity 3 (CAS CATO-C4X-18473)
- Ribociclib impurity 39 (CAS 2304957-86-4)
- N-Acetyl Demethyl Memantine (CAS 778-09-6)
- 4-Methoxy-N-(4-oxo-1,4-dihydroquinazolin-2-yl)benzamide (CAS 77478-79-6)
- (4-(3-Oxocyclobutyl)phenyl)boronic acid (CAS 254893-03-3)
- N-(4-amino-2-methoxyphenyl)adamantane-1-carboxamide (CAS 299935-94-7)
- 4-(2-Methoxy-5-nitrophenyl)butan-2-one (CAS 1099653-17-4)
- 2-Amino-5-bromo-3-(trifluoromethyl)benzaldehyde (CAS 1806044-68-7)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com